If you havent before, please take a look at the following
Gears of War 4 must be installed to an NTFS drive otherwise it may fail to install, run or update properly.
You make sure that the Windows EFS service is running in order to run the title. Do not disable it.
Some players have reported that the title will not boot when the Windows automatic update service is disabled. Enabling the automatic update service will resolve this issue.
Edit: Also if you havent try clean reinstalling the Nvidia drivers through Geforce experience.